Statins | Indication | Dose | Side effects | Brand name of some available preparations in BD market |
Fluvastatin | Type 2 hyperlipidaemia, retardation of coronary atherosclerosis and not responding adequately to dietary control. | 20-40mg/day (evening) | · Dyspepsia · Nausea · Abdominal pain · Insomnia · Urticarial | Lescol (Novartis) 20 mg Tk. 19.90/Cap, 40 mg Tk. 27.49/Cap |
Simvastatin | type 2 hyperlipidaemia which condition is not respond to diet control adequately;patients having CHD with plasma cholesterol level 5.5mmol/l or higher;concomitant therapy with immunosuppressives. | Primary hypercholesterolaemia,combined hyperlipidaemia,10 mg daily at night, to be adjusted at intervals of 4 weeks;coronary heart disease,20 mg once daily at night, to be adjusted at intervals of 4 weeks;max. 80 mg daily(once). | Same as that of fluvastatin | Avastin (Beximco) Novastin (Drug Int.) Recol (ACI) Sim (Opsonin) Simvastin (acme) Vastocor (incepta) |
Lovastatin | hypercholesterolaemia (plasma cholesterol level > 5.5 mmol/l); to end the progession of coronary heart disease | Primary hypercholesterolaemia, combined hyperlipidaemia, 20 mg/day with the evening meal. | · Chest pain · Alopecia · Acid reflux · Pruritis · dry mouth | Lovatin (Ambee), Tab 20 mg Tk. 10.11/Tab |
Atrovastatin | the treatment of hypercholesterolaemias as well as mixed hyper-lipidaemia. | PO as Calcium salt; initial dose is 10 mg/day which is taken at intervals of 4 weeks upto a max. of 80 mg daily. | Same as that of fluvastatin | Anzitor (Square) Astin (Jayson) Atova (Beximco) Avas (Opsonin) Divastin (Drug Int.) Tiginoor (Incepta) |
Short-acting statins(PO) are given at night to reduce peak cholesterol synthesis in the early morning.They are generally absorbed and extracted by the liver,their site of action & are subjected to widespread presystemic metabolism via cyt P450 & glucuronidation pathways. Simvastatin is an inactive lacton prodrug; it is predominantly metabolized in the liver to form the corresponding active beta-hydroxy fatty acid.
Clinical Uses:
· Atrovastatin lowers serum cholesterol in patients with homozygous familial hypercholesterolaemia.
· In severe drug resistant dyslipidaemia (e.g. heterozygous familial hypercholesterolaemia).Ezetimide is combined with statin treatment.
Compareand Contrast between Enzyme and Hormone
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Compareand Contrast between Enzyme and Hormone
Please click here you can know health information from my web site.
